Uptake of human papilloma virus vaccine and its associated factors among adolescent girls in Gambella town, Southwest, Ethiopia, 2022.A community -based cross-sectional study.

Abstract

Background: Globally, cervical cancer is one of the most common forms of carcinoma among women, leading high morbidity and mortality. Ethiopia launched the human papilloma vaccination

for the first time, with the support of the Global Alliance for Vaccine and Immunization in 2018. However, there is little evidence on uptake of Human Papilloma Virus (HPV) vaccine among adolescent girls. Even the existing one is institutional based study,

which is not generalizing adolescent population.

Objective: To assess the uptake of HPV vaccine and its associated factors among adolescent

girls in Gambella town, Southwest Ethiopia 2022.

Methods:

A community-based cross-sectional study was conducted from May 28, 2022 to July, 4, 2022 in Gambella town, Southwest Ethiopia. A cluster random sampling technique was used to select 882 study participants. An interviewer administered and pretested questionnaires were

used to collect the data. The data was collected by 4 female diploma nurses and 1 female degree-holder nurse supervisor. The collected data was entered in to Epi-data version 4.6, and exported to STATA version 16 for cleaning, coding and analysis. Bi-nary logistic regression model was used to test association between independent and dependent variables. Variables with a p-value <0.05 in the multivariable logistic regression were considered as a statistically significant factor for uptake of HPV vaccination.

Results:

A total of 825 adolescent girls participated in this study with 93.5% of response rate.Among participants,396(48%)(95%CI,44.6%-51.4%) have been vaccinated for HPV.The variable such as ever heard about HPV vaccine(AOR=2.5,95%CI,1.23-5.08),knowledge of infection,(AOR=3.62,95%CI,2.17-6.02),knowledge of HPV vaccine,(AOR=5.54,95%CI, 3.28-9.36) and attitude toward HPV vaccine (AOR=2.74,95%,CI,1.88-3.98) were significantly associated with uptake of HPV vaccine.

Conclusion

and recommendation. In the current study, the uptake of HPV vaccination is found to low.Ever heard about HPV vaccine, knowledge of HPV infection, knowledge of HPV vaccine and attitude toward HPV vaccine were significantly associated with uptake of HPV vaccination. Therefore, community health education on HPV infection and vaccine are necessary to increase knowledge of HPV vaccine, to build positive attitude and to improve uptake of HPV vaccination. Key-words: Human Papilloma Virus, HPV vaccine, knowledge, attitude to HPV vaccine, uptake, adolescent girls