Abstract:
The study of electrochemical determination of paracetamol and para-aminophenol was
investigated by electroanalytical techniques such as CV and DPV on activated glassy carbon
electrode. The GCE was activated by applying a potential of 1750 mV for 200 s in time based
technique phosphate buffer solution followed by potential cycling 0.0 to 700 mV for six cycles.
Activated GCE was chosen for simultaneous determination of paracetamol and para-amino
phenol and it showed an excellent electrocatalytic effect and decreases the overpotential than
bare GCE. Electrochemical reaction of APAP and PAP at AGCE was found to be reversible
involving the transfer of two electron and two proton processes. Phosphate buffer solution pH 6
was used as a solvent and supporting electrolyte for the analysis of standard paracetamol and
para-aminophenol throughout the experiment. The peak to peak separation of APAP and PAP is
271.1 mV, which is sufficient for simultaneous determination of the two analytes. The
electrochemical reaction of APAP and PAP was adsorption controlled process. The oxidation
peak current linearly dependent on the concentration of APAP in the range of 4 mol L-1 to 60
mol L-1 at constant concentration of PAP and concentration of PAP in range of 10 mol L-1 to
240 mol L-1 at constant concentration of APAP. The LOD of APAP and PAP were found to be
1.46 x 10-7 mol L-1 and 3.24 x 10-7mol L-1 respectively and LOQ of APAP and PAP were 4.87 x
10-7 mol L-1 and 1.08 x10-6 mol L-1 respectively. Validation of the method was also checked with
recovery studies and interferences were also studied.
