Assessment of coagulopathy and its associated factors among bleeding diathesis patients attending at University of Gondar Specialized Referral Hospital, Northwest Ethiopia

Abstract

ABSTRACT Background: Hemostasis is a process that prevents and stops bleeding. It has four compartments and a defect in any of these results coagulopathy. Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, 26% - 45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or Inhibitory. Objective: This study was aimed to assess coagulopathy and its associated factors among bleeding diathesis participants attending at University of Gondar Specialized Referral Hospital. Methodology: A hospital-based cross-sectional study was conducted among 384 (210 male and 174 female) study participants attending at University of Gondar specialized referral hospital from January to May 2020. Participants were recruited by a convenient sampling technique. Sociodemographic and clinical characteristics were collected using questioner. Besides, 6.8ml venous blood was collected by using EDTA and 3.2% sodium citrated anticoagulated tubes for platelet count, and coagulation tests respectively. For those study participants with prolonged coagulation tests mixing test was done to differentiate factor deficiency from its inhibitors. Furthermore, blood film and stool examination were done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Normality was checked by using the skewness and kurtosis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the association, and a P-value less than 0.05 was considered as statistically significant. Result: The overall prevalence of coagulopathy was 253 (65.9%). From the total study participants, 199 (51.8%) of them showed prolonged coagulation time, and 123 (32.0%) showed thrombocytopenia. Among those participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1%. Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy. Conclusion: Coagulopathy due to inhibitory was a high public health problem in this study. The participant with cardiac and other chronic disease was associated with coagulopathy. Keywords: - Bleeding diathesis, Coagulopathy, Mixing test, Gondar, and Ethiopia