Abstract:
ABSTRACT
Background: Hemostasis is a process that prevents and stops bleeding. It has four compartments
and a defect in any of these results coagulopathy. Coagulopathy is the major cause of mortality
and morbidity throughout the world. Globally, 26% - 45% of healthy people have a history of
bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or Inhibitory.
Objective: This study was aimed to assess coagulopathy and its associated factors among bleeding
diathesis participants attending at University of Gondar Specialized Referral Hospital.
Methodology: A hospital-based cross-sectional study was conducted among 384 (210 male and
174 female) study participants attending at University of Gondar specialized referral hospital from
January to May 2020. Participants were recruited by a convenient sampling technique. Sociodemographic and clinical characteristics were collected using questioner. Besides, 6.8ml venous
blood was collected by using EDTA and 3.2% sodium citrated anticoagulated tubes for platelet
count, and coagulation tests respectively. For those study participants with prolonged coagulation
tests mixing test was done to differentiate factor deficiency from its inhibitors. Furthermore, blood
film and stool examination were done for malaria and intestinal parasite identification,
respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS
version-20 for analysis. Normality was checked by using the skewness and kurtosis. Descriptive
statistics were summarized as percentages, means, and standard deviations. Bivariate and
multivariate logistic regression was used to identify the association, and a P-value less than 0.05
was considered as statistically significant.
Result: The overall prevalence of coagulopathy was 253 (65.9%). From the total study
participants, 199 (51.8%) of them showed prolonged coagulation time, and 123 (32.0%) showed
thrombocytopenia. Among those participants with prolonged coagulation time, the prevalence of
factor deficiency was 21.1%. Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic
diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy.
Conclusion: Coagulopathy due to inhibitory was a high public health problem in this study. The
participant with cardiac and other chronic disease was associated with coagulopathy.
Keywords: - Bleeding diathesis, Coagulopathy, Mixing test, Gondar, and Ethiopia
