Abstract:
Abstract
Background: Hyperuricemia is associated with cardiovascular disease and also its high
prevalence linked with increases the risk of cardiovascular disease among diabetes mellitus
patients. Cardiovascular complication is a major complication that causes death among diabetic
patients if they failed to control their blood glucose level. The main aim of this study was to
assess serum uric acid and its association with cardiovascular disease risk factors among
diabetic patients at University of Gondar Hospital, Northwest Ethiopia.
Methods: A cross-sectional study was carried out at the University of Gondar hospital from
February to March 2018. A total of 384 study participants were selected by systematic random
sampling technique. Socio-demographic and anthropometric data was collected by using semi
structured questionnaire. Five milliliter blood sample was collected and analyzed for glucose,
uric acid, and lipid profiles through Mindray BS-200E. The data was entered into SPSS version
20 for analysis. Descriptive statistics and logistic regression model was used to investigate
frequencies and associated factors. In addition, Pearson抯 correlation was used for the correlation
of clinical and biochemical parameters. A p value <0.05 was considered as statistically
significant.
RESULTS: The prevalence of hyperuricemia among type 2 diabetic patients was 31.5% (n =
121). The serum uric acid concentration was higher among male (33.1%) compared to female
(28.9%). The prevalence was higher among age group> 45 years (31.8%). Increased systolic
blood pressure (AOR: 4.4, 95%CI: 2.1-9.3), family history of diabetic抯 mellitus (AOR: 1.5,
95%CI: 1.2-2.5) and body mass index ? 25 Kg/m2 (AOR: 1.4, 95% CI: 1.1-3.7) were
significantly associated with hyperuricemia. The major cardiovascular risk factors including high
body mass index (52.4%), high waist circumference (63.0%) and high systolic blood pressure
(58.2%) are higher for our study participants.
CONCLUSION: The prevalence of serum uric acid was high in type 2 diabetes patients. The
major predictors of cardiovascular risk factors were significantly associated with hyperuricemia.
Therefore, early diagnosis and treatment for hyperuricemia and cardiovascular disease risk
factors are essential to reduce cardiovascular disease in type 2 diabetic patients.
Key word: Hyperuricemia, diabetes mellitus, cardiovascular disease
