Abstract:
Abstract— A simple and fast modification of bare glassy
carbon electrode (GCE) by electropolymerization of L-aspartic
acid (L-Asp) using cyclic voltammetry was reported for the detection of ibuprofen (IBP). The poly(L-Asp)/GCE was characterized
by cyclic voltammetry, electrochemical impedance spectroscopy,
and electroactive surface area measurements. The cyclic voltammetric and square wave voltammetric study of IBP in 0.25-M
acetate buffer solution at pH 4 showed an obvious electrocatalytic
effect toward IBP oxidation, which resulted in a higher current
response and a negative shift in the peak potential, at the polymer
film modified electrode compared with the bare GCE. Under the
optimized conditions, a calibration curve was obtained by the
square wave voltammetry at the poly(L-Asp)/GCE. The square
wave voltammetric peak current linearly varied with IBP concentrations in the range of 1.0 × 10−6 M to 1.5 × 10−4 M with the
limit of detection (3Sb/m) and the limit of quantification (10Sb/m)
of 2.2 × 10−7 and 7.4 × 10−7 M, respectively. The method was
successfully applied for the determination of IBP in pharmaceutical formulations and biological samples with satisfactory recovery
values, 90%–108%. The proposed sensor also demonstrated good
selectivity, repeatability, and reproducibility with appreciable
long term stability.
Index Terms—Poly(L-aspartic acid), ibuprofen, tablets, urine,
square wave voltammetry.
