Prevalence and Associated Factor of Brown Adipose Tissue: Systematic Review and Meta-Analysis

dc.contributor.author	Gebrie, Misganaw
dc.contributor.author	Sisay, Wullo
dc.contributor.author	Abebaw Angaw, Dessie
dc.contributor.author	Antehunegn Tesema, Getayeneh
dc.date.accessioned	2021-07-07T12:45:11Z
dc.date.available	2021-07-07T12:45:11Z
dc.date.issued	2021-07-07
dc.identifier.uri	http://hdl.handle.net/123456789/3682
dc.description.abstract	3.1. Search Results. A total of 837 articles were retrieved from different electronic databases. After removal of 300 duplicate articles, 492 of the studies were excluded based on review of the title and abstract. From these, 45 publications were considered for full-text review and 23 of the studies were excluded because they did not report the total prevalence clearly and some article estimates the prevalence of brown adipose tissue in a specific anatomical location of the body. Finally, 22 peer-reviewed papers were included for qualitative analysis. After eligibility evaluation, 8 papers which	en_US
dc.description.sponsorship	uog	en_US
dc.language.iso	en	en_US
dc.publisher	BioMed Research International	en_US
dc.subject	EndNote, and duplicates were removed. Two researchers (MG and GA) independently assessed the titles and abstracts and reviewed the full text of the eligible citations, and for any discrepancy, the third reviewer (DA) made the final decision. For each included study, two researchers (DA and WS) independently extracted the following information: general information (e.g., first author, title, journal, and publication year), study characteristics (including study period, study area, study design, sample source, sample selection method, and sample size), and all possible participant information. Two researchers (MG and GA) independently assessed the quality of each included study using NOS quality assessment tools. Only when the reviewers agreed was the study included in the qualitative and quantitative analysis. The retained articles were required to have a minimum quality score requirement. 2.4. Statistical Analysis. We used a systematic approach to estimate the pooled prevalence of brown adipose tissue from all eligible studies. A fixed-effect model was selected to summarize the prevalence of brown adipose tissue, using statistical tests for heterogeneity. Heterogeneity among studies was assessed using Cochran’s Q test and I2 statistic. Since the data showed moderate heterogeneity (I2 < 75%), a fixed-effect model was used. Subgroup analyses by geographic region and the year of study were performed to address heterogeneity and to have pooled prevalence across different regions and estimation of prevalence of BAT at different periods. Additionally, sensitivity analysis (i.e., recalculating the pooled estimate by omitting studies) was performed to assess the influence of any particular study on the pooled prevalence. Publication bias was assessed using Egger’s tes	en_US
dc.title	Prevalence and Associated Factor of Brown Adipose Tissue: Systematic Review and Meta-Analysis	en_US
dc.title.alternative	Prevalence and Associated Factor of Brown Adipose Tissue: Systematic Review and Meta-Analysis	en_US
dc.type	Article	en_US