ComparisonofcoagulationandplateletparametersamongTreatmentNaïve,TreatmentReceivingNon-Hodgkin’sLymphomaPatientsandHealthyControlsatNorthwestEthiopia:AComparativeCross-SectionalStudy

dc.contributor.author	Marelgn, Lyusira
dc.date.accessioned	2025-07-25T07:57:55Z
dc.date.available	2025-07-25T07:57:55Z
dc.date.issued	2025-07-25
dc.identifier.uri	http://hdl.handle.net/123456789/10139
dc.description.abstract	ackground:Non-Hodgkinlymphomaisacollectionofdiverselymphoidneoplasmswithdistinctbiological properties. Ithasbeen linkedwithcoagulationproblems.Coagulopathyincreasesmorbidityandmortality.However,thereislimitedinformationregardingcoagulationandplateletparametersinnon-Hodgkin’slymphomapatientsinEthiopia. Objective:Thisstudyaimedtocomparecoagulationandplateletparametersamongtreatment-naïve,treatment-receivingNon-HodgkinsLymphomapatientsandhealthy controls. Methods:Acomparativecross-sectionalstudywasconductedattheUniversityofGondarandFelegehiwotComprehensiveSpecializedHospitalsfromJuly01,2024,toFebruary25,2025.Atotalof180studyparticipantswereenrolledusingaconvenientsamplingmethod.Thesocio-demographicandclinicaldatawascollectedbystructuredquestionnairesandmedicalrecordreview.Eightmlofbloodwerecollected:3mlinEDTA,2.7mlintrisodiumcitrate,and2mlinserumseparatortubes.PlateletandcoagulationparametersweremeasuredusingMindray-5150hematologyanalyzerandGenruicoagulationanalyzer(CA51).ThecollecteddatawasenteredandclearedbyEpiData3.1andwasanalyzedbySPSSversion21.TheKruskal-Wallistestwasemployedtocomparecoagulationparametersamongthethreegroups.Spearmancorrelationwasperformedtodeterminetherelationshipbetweenvariables.Theresultwaspresentedusingcharts,tablesandtexts.P-value<0.05wasconsideredstatisticallysignificant. Result:Themeanage±SDofthestudyparticipantswas51±16,51±15and49±6yearsfortreatment-experienced,treatment-naïve,andhealthycontrols,respectively.59.4%ofthestudyparticipantsweremale.Themedian(IQR)valueofaPTTwere39.2(15.2),43.8(17.5),and33.2(8.2)secondsfortreatment-naïve,treatment-receiving,andhealthycontrolgroups,respectively.Themedian(IQR)PTvaluesfortreatmentnaive,treatmentexperienced,andhealthycontrolswere15.6(3.79),17.16(6.43),and14.6(10.85)seconds,respectively.BothActivatedPartialThromboplastinTimeand IX Prothrombintimeshowstatisticallysignificantvariationamongthethreegroups(p-value<0.001).Besides,themedian(IQR)ofplateletcountshowedasignificantdifferenceamongtreatmentnaive,treatmentexperiencedandhealthycontrolgroups(p<0.001),withmedianvalueof191(145.5),178(118),and254(62.5),respectively. Conclusion:Plateletandcoagulationparametersshowedsignificantdifferenceamongthethreegroups.TheresultsrevealasignificantcoagulationabnormalitiesinNHLpatients, indicatingtheneedforroutinehemostaticmonitoringtofacilitateearlyinterventionandmanagement	en_US
dc.description.sponsorship	uog	en_US
dc.language.iso	en	en_US
dc.subject	Non-Hodgkin’s lymphoma,Coagulationparameter,Platelet parameter, Ethiopia	en_US
dc.title	ComparisonofcoagulationandplateletparametersamongTreatmentNaïve,TreatmentReceivingNon-Hodgkin’sLymphomaPatientsandHealthyControlsatNorthwestEthiopia:AComparativeCross-SectionalStudy	en_US
dc.type	Thesis	en_US