Objectives: Empirical selections of antimicrobial therapy based on clinical observations are common clinical prac tices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility  testing in northwest Ethiopia.  Results: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51),  blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections. Patho genic bacteria were isolated among 62.4%(131) cases. The distributions of bacteria detected in conjunctivitis, dacryo cystitis, and blepharitis patients were 32.8%(43), 23.7%(31), and 16.0%(21), respectively. The most prevalent isolates  were coagulase negative Staphylococci; 27.5%(36), S. aureus; 26.7%(35), Pseudomonas species; 10.7%(14), and E. coli;  7.6%(10). Tetracycline, amoxicillin, chloramphenicol, ampicillin, and nalidic acid showed resistance to bacterial isolates  with a respective prevalence of 35.9%(47), 32.1%(42), 26.2%(34), 25.2%(33), and 23.7%(31). Multi-drug resistance pat terns to the commonly prescribed antibiotics tested was 20.6%(27), 18.3%(24), 17.6%(23), 5.3%(7), and 4.6%(6) to two,  three, four, five, and six antibiotics, respectively. Overall, the multi-drug resistance prevalence rate was 66.4%(87). This  study confirmed diverse types of external ocular manifestations associated with bacterial infections with wide ranges  of antibiotic resistant phenotypes. Thus, combining clinical information, bacteriological analysis, and antimicrobial  susceptibility tests are useful for making an evidence-based selection of antibiotics therapy.  Keywords: Ocular infections, Antibiotic resistance, Ethiop

Objectives: Empirical selections of antimicrobial therapy based on clinical observations are common clinical prac tices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. Results: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections. Patho genic bacteria were isolated among 62.4%(131) cases. The distributions of bacteria detected in conjunctivitis, dacryo cystitis, and blepharitis patients were 32.8%(43), 23.7%(31), and 16.0%(21), respectively. The most prevalent isolates were coagulase negative Staphylococci; 27.5%(36), S. aureus; 26.7%(35), Pseudomonas species; 10.7%(14), and E. coli; 7.6%(10). Tetracycline, amoxicillin, chloramphenicol, ampicillin, and nalidic acid showed resistance to bacterial isolates with a respective prevalence of 35.9%(47), 32.1%(42), 26.2%(34), 25.2%(33), and 23.7%(31). Multi-drug resistance pat terns to the commonly prescribed antibiotics tested was 20.6%(27), 18.3%(24), 17.6%(23), 5.3%(7), and 4.6%(6) to two, three, four, five, and six antibiotics, respectively. Overall, the multi-drug resistance prevalence rate was 66.4%(87). This study confirmed diverse types of external ocular manifestations associated with bacterial infections with wide ranges of antibiotic resistant phenotypes. Thus, combining clinical information, bacteriological analysis, and antimicrobial susceptibility tests are useful for making an evidence-based selection of antibiotics therapy. Keywords: Ocular infections, Antibiotic resistance, Ethiop

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dc.contributor.author	Belyhun, Yeshambel
dc.contributor.author	etal
dc.date.accessioned	2025-03-12T08:51:51Z
dc.date.available	2025-03-12T08:51:51Z
dc.date.issued	2025-03-12
dc.identifier.uri	http://hdl.handle.net/123456789/8758
dc.description.abstract	A total of 143 participants of HBV-HIV co-infected (n = 48), HBV mono-infected blood donors (n = 43) and chronic liver disease (CLD) patients (n = 52) were included in the study. The BCP/PC genome regions responsible for HBeAg expression from the EcoRI site (nucleotides 1653±1959) were sequenced and analyzed for the BCP/PC mutant variants.	en_US
dc.description.sponsorship	uog	en_US
dc.language.iso	en	en_US
dc.subject	A total of 143 participants of HBV-HIV co-infected (n = 48), HBV mono-infected blood donors (n = 43) and chronic liver disease (CLD) patients (n = 52) were included in the study. The BCP/PC genome regions responsible for HBeAg expression from the EcoRI site (nucleotides 1653±1959) were sequenced and analyzed for the BCP/PC mutant variants.	en_US
dc.title	Objectives: Empirical selections of antimicrobial therapy based on clinical observations are common clinical prac tices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. Results: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections. Patho genic bacteria were isolated among 62.4%(131) cases. The distributions of bacteria detected in conjunctivitis, dacryo cystitis, and blepharitis patients were 32.8%(43), 23.7%(31), and 16.0%(21), respectively. The most prevalent isolates were coagulase negative Staphylococci; 27.5%(36), S. aureus; 26.7%(35), Pseudomonas species; 10.7%(14), and E. coli; 7.6%(10). Tetracycline, amoxicillin, chloramphenicol, ampicillin, and nalidic acid showed resistance to bacterial isolates with a respective prevalence of 35.9%(47), 32.1%(42), 26.2%(34), 25.2%(33), and 23.7%(31). Multi-drug resistance pat terns to the commonly prescribed antibiotics tested was 20.6%(27), 18.3%(24), 17.6%(23), 5.3%(7), and 4.6%(6) to two, three, four, five, and six antibiotics, respectively. Overall, the multi-drug resistance prevalence rate was 66.4%(87). This study confirmed diverse types of external ocular manifestations associated with bacterial infections with wide ranges of antibiotic resistant phenotypes. Thus, combining clinical information, bacteriological analysis, and antimicrobial susceptibility tests are useful for making an evidence-based selection of antibiotics therapy. Keywords: Ocular infections, Antibiotic resistance, Ethiop	en_US
dc.type	Article	en_US