Survival and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. A retrospective follow-up study

Abstract

A total of 271 TB/HIV co-infected children were included in the analysis. Of these, 38 (14.02%) children were died during the follow-up period. This gives a total of 1167.67 childyears of observations. The overall mortality rate was 3.27(95%CI: 2.3±4.5) per 100 childyears. The independent predictors of time to death were age 1±5 years (as compared to age <1 year) (AHR = 0.3; 95%CI:0.09±0.98)), being anemic (AHR = 2.6; 95%CI:1.24±5.3), cotrimoxazole preventive therapy(CPT) non-users (AHR = 4.1; 95%CI:1.4±16.75), isoniazid preventive therapy(IPT) non-users (AHR = 2.95; 95%CI:1.16±7.5), having extra pulmonary tuberculosis(EPTB) (AHR = 2.43; 95%CI:1.1±5.3)) and fair or poor adherence to Anti-Retroviral Therapy (ART)(AHR = 3.5; 95%CI:1.7