Isolation, Structural Elucidation and Bioactivity Studies of Tropane Derivatives of Alkaloids from Seeds Extract of Datura Stramonium

Abstract

Datura stramonium (Solanaceae) is a plant species distributed throughout most parts of temperate regions of the world and is a noxious weed of cultivated cereal crops. The plant has medicinal value and is important in traditional medicine like the other species in the genus. The aim of this study was to isolate, purify and characterize the bioactive principle from the seeds of the plant. For isolation of the compound, the air dried seeds powder (125 g) of plant was soaked at room temperature for 12 hr with MeOH (500ml) and extracted using rotary evaporator. The crude extracts were showed a wide range of zones of inhibition against all the tested bacterial strains. The isolated and purified afforded white crystalline powder (TA) was subjected to spectral identification by IR, 1H- NMR, 13C-NMR, DEPT-135 and GC‐MS. The isolated compound was concluded as 3-(3'-methoxytropoyloxy)-6-tigloyloxy -7-Hydroxy tropane