CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY AND ASSOCIATED FACTORS AMONG CANCER PATIENTS IN UNIVERSITY OF GONDAR COMPREHENSIVE SPECIALIZED HOSPITAL AND FELEGEHIWOT COMPREHENSIVE SPECIALIZED HOSPITAL, NORTH WEST ETHIOPIA, 2019

Abstract

ABSTRACT Background: Chemotherapy induced peripheral neuropathy is one of the most prevalent neurologic complications of cancer treatment. Despite this, current evidences suggesting that Chemotherapy induced peripheral neuropathy were under-reported, under-diagnosed, and undertreated in the world. Studies in developing country are lacking. Therefore, this research is crucial to clearly state its prevalence and to identify the contributing factors of Chemotherapy induced peripheral neuropathy. Objective: The main purpose of this study was to assess prevalence and associated factors of chemotherapy induced peripheral neuropathy among cancer patients in the oncology unit of the university of Gondar comprehensive specialized hospital and Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia, 2019. Methods: An institution based cross sectional study was conducted at the university of Gondar comprehensive, specialized hospital and Felege Hiwot Comprehensive, Specialized Hospital. Data was collected by interviewing the participants using a structured questionnaire and medical chart review through trained data collectors. Participants were selected through systematic random sampling technique. Chemotherapy induced peripheral neuropathy was assessed through the European organization of research and treatment quality of life questionnaire. Data was analyzed using descriptive statistics, binary and multivariate logistic regression methods. AOR with P value <0.05 with 95% CI was considered statistically significant. Results. A total of 302 cancer patients were included in this study with response rate100%. The overall prevalence of Chemotherapy induced peripheral neuropathy among cancer patients were 37.4 % ( Conclusion. The prevalence of Chemotherapy induced peripheral neuropathy in this study was high. Being old age, alcoholic, diabetic and anemic were significantly associated. Keywords: prevalence, risk factors, Chemotherapy induced peripheral neuropathy, Ethiopia