Abstract:
Abstract
Introduction: Drug related hospital admission is a hospitalization due to one of the drug
related problems; which is an event involving drug therapy that actually or potentially
interferes with the desired therapeutic outcome. Drug related problems are prevalent with the
range of from 13% to 41.3% worldwide. Unless timely recognized and made necessary
intervention, drug-related problems may eventually lead to hospital admission.
Objective: This study was aimed at assessing the prevalence, and associated factors of drug
related hospital admission among adult patients admitted to the medical wards of the Felege
Hiwot Comprehensive Specialized Hospital (FHCSH).
Method: Across-sectional study was conducted at the internal medicine wards of Felege
Hiwot Comprehensive and Specialized Hospital fromJune1 to September 15, 2020.
Structured questionnaires and an assessment tool for drug related hospital admission, ATHARM10
tool,
were used for data collection by two clinical pharmacists from July 1 up to
September 15, 2020, prospectively. The data was entered into Epidata 4.7.2 software, then
transformed to Statistical Package for Social Sciences (SPSS® (IBM Corporation)) software
version 24 for analysis. Descriptive statistics were presented by using frequency and
proportion. Binary logistic regression was applied to identify factors associated with drug
related hospital admission with a 95% confidence level and a p-value of 0.05.
Result: The prevalence of drug related hospital admissions was 31.9% (95% CI = 27.7%36.4%).
From this, non-compliance 37.8% (95% CI = 29.6 - 45.9), untreated indication
31.9% (23.7 - 40), and adverse drug reaction 15.6% (95% CI = 9.6 – 21.5), accounts the three
top drug related hospital admission. About 28.8 % of all admissions, were preventable. The
most of drug related hospital admissions were moderate (76.3) to severe (21.5) and
preventable (80.7). Patients with lower to medium Charlson comorbidity index score, longer
duration of therapy, and who did not have health insurance significantly associated with drug
related hospital admissions.
Conclusion and recommendation
The prevalence of drug related hospital admissions was considerably high. Non-compliance
and untreated indications were the commonest drug related problems that caused drug related
hospital admissions. Emphasis should be given on drug therapy optimization to prevent and
manage drug related problems.
Key Words: drug related hospital admission, drug related problems, prevalence, associated
factors, patterns, Bahir Dar, Northwest Ethiopia.
