Abstract:
ABSTRACT
Background: Warfarin therapy is the basis for prevention and treatment of thromboembolic
disease; however, initiation of warfarin therapy is challenging because it has been associated
with plenty of problems such as bleeding risk, interaction with various drugs and diet.
Objective: To evaluate the quality of anticoagulation and clinical outcome of patients on
warfarin therapy at University of Gondar comprehensive specialized hospital.
Method: A retrospective cross-sectional study design which analyzed data for eligible participants
treated between June 2016 and June 2018 was carried out at University of Gondar comprehensive
specialized hospital Ethiopia. Two hundred two files of adult patients on warfarin anticoagulation who
met the study inclusion criteria were reviewed. The percentage of time spent in therapeutic range
was calculated by Rosendaal Linear Interpolation method. The data was analyzed by SPSS
version 20.0. Multivariate binary logistic regression was used to identify independent predictors
of poor anticoagulation control. Statistical significance was determined at 95% confidence
interval and p-value 0.05.
Result: A total of 202 patients were included in this study and the mean age of participants was
44.33 years
percentage of TTR was 41% with SD ±35.46%. Twenty seven patients experienced adverse drug
events; from these 9 patients
Conclusion: Quality of warfarin anticoagulation for various indications receiving medical care
in UoGCSH was poor so that strong effort is needed to improve the level of anticoagulation
control. Co-morbidity and potential drug interaction needs special attention.
Keyword: warfarin, quality of anticoagulation, UoGCSH, TTR.
