Abstract:
Abstract
Back ground:Hematological manifestations are seen at every stage of Human Immunodeficiency
Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) and often pose a great challenge in the
comprehensive management. The pathophysiological basis for these may include impaired
hematopoiesis, immune-mediated cytopenias, and/or coagulopathies especially in the advanced stage
of the disease.
Objective: The aim of this study was to determine, magnitude hematological abnormalities and its
correlation with Cluster of Differentiation 4(CD4) cell counts and Viral Load (VL) among Highly
Active Antiretroviral Therapy (HAART) experienced adult HIV patients, at Northwest Ethiopia.
Material and Method: Across-sectional study was conducted on 215 HAART experienced patients,
who were recruited by systematic random sampling. Socio-demographic and clinical data were
collected by structured questionnaire and laboratory data were obtained after 5ml of Ethylene Diamine
Tetra Acetic acid (EDTA) anti coagulated blood was drawn and tested.Beckman Coulter UniCelDxH
800, BD-FACS Presto and Abbott Real Time HIV-1 analyzer were used to determine the
hematological parameter, CD4 cell count andVL test respectively. EP INFO and SPSS version 25
(IBM Corporation, Armonk, NY, USA) software were used for data entry and analysis,
respectively.Descriptive analysis were done and results were presented as frequency, median, Inter
Quartile Range (IQR), percentage and mean ± SD. Spearman’s correlation coefficient was used for
comparison of median values of hematological parameters, with CD4 cell counts and VLs. The results
of the analysis were presented with tables and figures. P-value less than 0.05 were considered as
statistically significant.
