The magnitude of coagulopathy and associated factors among adult type II diabetes mellitus patients attending at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Abstract

ABSTRACT Introduction: Diabetes mellitus is a heterogeneous disorder of metabolism which results in chronic hyperglycemia. The hyperglycemia state affects the coagulation pathway and results in malfunctioning of clot formation, fibrinolysis, platelet, and endothelial tissues. Atherothrombotic complications are the leading cause of death in diabetes mellitus patients. Objectives: This study aimed to determine the magnitude of coagulopathy and associated factors among adult Type II diabetes mellitus patients attending the University of Gondar Comprehensive Specialized Hospital Northwest Ethiopia. Methods: A facility-based cross-sectional study was conducted among 357 study participants. A convenient sampling technique was used to select study participants. Face to face interview was used to collect the socio-demographic data. The clinical data were collected from the patient’s medical chart using a data collection sheet. Six milliliters of venous blood samples were collected to perform coagulation tests and complete blood count. For abnormally prolonged coagulation results, a mixing test was performed. Data were entered into EpiInfo version 7.2.4.0 and exported to SPSS version 20 for statistical analysis. Then descriptive statistics were presented in texts, tables, and figures. A binary logistic regression model was used to identify risk factors. A P-value of < 0.05 was considered statistically significant. Results: The magnitude of coagulopathy was 26.6% (95% CI: 22.1, 31.5%). Out of this abnormality, 12.3% showed shortened prothrombin time and 8.7% showed shortened activated partial thromboplastin time. In addition, the prevalence of prolonged prothrombin time tests was 5.6%. From the prolonged prothrombin time, the prevalence of factor deficiency and inhibitors were 95% and 5%, respectively. The prevalence of the prolonged activated partial thromboplastin time test was 3.9%. Out of this, the prevalence of factor deficiency and inhibitors were 92.8% and 7.14%, respectively. Being Female (AOR= 2.06; 95% CI: 1.11-3.85%), abnormal BMI (AOR=1.94; 95% CI: 1.08-3.50), and High school (AOR= 0.26; 95% CI: 0.10- 0.83%) were significantly associated with hypercoagulation Conclusions and recommendations: The prevalence of coagulopathy among T2DM patients was high. Being Female and having abnormal BMI were associated with an increased risk of hypercoagulation. Regular monitoring of coagulation parameters should be performed