Abstract:
Abstract
Background: Leishmaniasis is a life-threatening parasitic disease next to malaria, which is
responsible for the death of 50,000 patients annually. It has three major clinical stages including
visceral, cutaneous and mucocutaneous leishmaniasis. The former one is called kala-azar. Eastern
Africa, the second largest VL endemic area following the Indian subcontinent, contributes to the
high global burden with 30,000� 40,000 new cases per year, of which Ethiopia, South Sudan and
Sudan accounts the largest proportion from cases. In Ethiopia the most common leishmaniasis foci
are Omo and Aba-Roba plains and the Woyto and Segen River valleys in the Southern Nations,
Nationalities and Peoples� Regional State (SNNPR), metema and humera. From this Metemma,
Humera, and the bordering of Sudan are areas where incidence mostly occurs. There are so many
drugs for leishmaniasis including sodium stigbogluconate and paramomycine combined treatment
are the option in Ethiopia.
Objectives: To assess serum amylase and lipase and associated factors among patients taking
sodium stigbogluconate/paramomycine combined drugs at University of Gondar comprehensive
specialized hospital, Northwest Ethiopia 2020 G.C.
Method:Institutional based cross-sectional study was conducted at Gondar University
Comprehensive Specialized Hospital from February to September 2020 G.C. Convenient sampling
technique was used. Those who fulfill inclusion criteria were included in the study with written
informed consent. 5 ml of blood were taken by experienced health professional. Descriptive Data
were presented by table, chart and graphs. Data were cleared, entered by Epi-data version 3.1
then transfer to STATA 14.1 SE version and for analysis paired t-test were used, for factors and
multivariate regression were used.
Result: paired t-test showed that there was a significance mean difference between serum
pancreatic amylase and lipase before and after treatment. The serum amylase count showed
statistically significant increase (P<0.001),after treatment serum amylase was
141.2911�.07whencompared to that of before treatment51.3333 �.475. Similarly, serum
lipase count shows statistically significant increase (p<0.001), after treatment serum lipase was
123.942�.07 when compared to that of before treatment 37.1593�.81
