Assessment of Hyperuricemia and its Associated Factors among Hypertensive Patients attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2020

Abstract

ABSTRACT Background: Hypertension is a major public health problem in developing countries. Globally, nearly 1.13 billion adults had hypertension in 2015 and this is estimated to increase to 1.56 billion by 2025. Hyperuricemia is the important predictor of the progression of hypertension and is common in the hypertensive patients. Hypertensive patients with hyperuricemia are at higher risk of cardiovascular disease. Objectives: The aim of the study was to assess the prevalence of hyperuricemia and its associated factors among hypertensive patients attending at University of Gondar Comprehensive Specialized Hospital in 2020. Method: An institutional based cross-sectional study was conducted on 248 hypertensive patients, who were attending at University of Gondar Comprehensive Specialized Hospital from March to July, 2020. A convenient sampling technique was employed to select study participants. Socio-demographic and clinical characteristics were collected using a structured questionnaire via face-to-face interview and reviewing medical records respectively. The biochemical parameters were measured by using Mindray BS-200E chemistry analyzer. Data was entered using EpiData version 4.6.0.0 and analyzed using STATA vs. 14.0. Bivariable and multivariable binary logistic regression were fitted to identify factors associated with hyperuricemia. The odds ratio and 95% CI were calculated to assess the strength of the association and P-value<0.05 in the multivariable was considered as statistically significant. Results: A total of 248 patients were enrolled; 140 (56.5%) female. Mean age of patients were 57.9�.5 years. The overall prevalence of hyperuricemia was 42.3%; males had a prevalence of 36.1% and females of 47.1%. High waist circumference, high body mass index, dyslipidemia, low estimated Glomerular Filtration Rate, elevated fasting blood glucose, elevated total cholesterol, elevated triglycerides, elevated Low Density Lipoprotein cholesterol and low High Density Lipoprotein cholesterol were found to be significantly associated with hyperuricemia. Conclusion: The current study demonstrated that predominant existence of hyperuricemia, in hypertensive patients. Therefore, early diagnosis and monitoring of hyperuricemia are required before further complication occurred. Key words: Hyperuricemia, associated factor, hypertension, UoGCSH