Abstract:
Abstract: Fetuin-A is a plasma glycoprotein exhibiting multifaceted physiological and pathological functions. It has been determined
to be involved in various essential biological functions, such as regulation of calcium metabolism, osteogenesis, and insulin signaling
pathway. It also plays a crucial role in the pathogenesis of several disorders, including psoriasis. Psoriasis is a chronic systemic
inflammatory disorder caused by a constellation of environmental, immunogenic, and genetic factors. It has been shown that
dysregulation of cytokines mediated immune response is responsible for the development of psoriasis. Several recent publications
suggest that dysregulation of fetuin-A correlates with psoriasis disease activities, revealing its putative role in the development of
psoriasis. Furthermore, clinical application of fetuin-A as a diagnostic marker, prognostic predictor, and therapeutic target for different
clinical conditions is in progress, and some are showing promising outcomes. This review primarily focuses on the current understanding of the role of fetuin-A in the pathogenesis of psoriasis and its potential clinical applications, with a brief highlight of psoriasis
epidemiology and burden. The information was gathered systematically from various journals via electronic searches using various
search engines: PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. The studies involved were
restricted to English language. Conversely, articles written in other languages, studies done on fetuin B, or studies conducted on
other dermatological diseases were excluded from the review article.
