Abstract:
Background: Acute kidney injury is a common disorder worldwide, occurring in more than
13 million per year, 85% of whom live in developing countries. The high incidence of acute
kidney injury among type 2 diabetic patients is a major cause of morbidity and mortality.
There is limited data that address the incidence and predictors of acute kidney injury to apply
evidence-based interventions in developing countries including Ethiopia specifically in the
study area.
Methods: Institution-based retrospective follow-up study was conducted among 420 adults
with newly diagnosed type 2 diabetes patients from January 1, 2014, to December 31, 2019.
Log rank test and Kaplan–Meier curve were used to compare different categories of survival
probability. In a multivariable analysis, variable having a p-value <0.05 in the Cox, proportional hazard model was considered as independent predictors.
Results: Overall, 19.76% (95% CI; 16.2–23.8) of the study population developed acute
kidney injury, with a median follow-up period of 30.75 months. Congestive heart failure
[adjusted hazard ratio (AHR): 2.89 (95% CI; 1.62, 5.13)], chronic kidney disease [AHR: 2.92
(95% CI; 1.56, 5.48)], hypertension [AHR: 2.87 (95% CI; 1.20, 6.90)], and diabetic
nephropathy [AHR: 2.04 (95% CI; 1.13, 3.68)] were found to be predictors of acute kidney
injury.
Conclusion: The incidence of acute kidney injury among type 2 diabetes patients was high
in the study area. In patients with hypertension congestive heart failure, chronic kidney
disease, and diabetic nephropathy efforts should be made to diagnose AKI early and treat it –
in addition to better control accordingly among type 2 diabetes mellitus patients.
Keywords: incidence, acute kidney injury, predictors, type 2 diabetes, Gondar, Ethiopia
