Risk stratification and prognostic value of prothrombin time and activated partial thromboplastin time among COVID-19 patients

Abstract

Baseline PT at a cut-off value � 16.25 seconds differentiated severe COVID-19 patients from mild and moderate patients (AUC: 0.89, 95% CI: 0.83–0.95). PT also differentiated mild COVID-19 patients from moderate and severe patients at a cut-off value � 15.35 seconds (AUC: 0.90, 95% CI: 0.84–0.96). Moreover, alcohol drinkers were a 3.52 times more likely chance of having severe disease than non-drinkers (95% CI: 1.41–8.81). A one-year increment in age also increased the odds of disease severity by 6% (95% CI: 3–9%). An increment of � 0.65 seconds from the baseline PT predicted poor prognosis (AUC: 0.93, 0.87–0.99)