Abstract:
dhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death
among people’s living human immunodeficiency virus. Though manifold factors have reported as determinant factors
of antiretroviral
therapy
adherence
status,
perhaps
determinants
of non-adherence
differ
up on the activities
of
patients
in the study setting.
Methods: An institution based unmatched case–control study was conducted in Aksum town. Individuals who
had a 6-month follow-up with complete individual information were included in the study. Document review and
interviewer based techniques were used to collect the data. Binary logistic regression analysis was used to identify the
determinant factors of non-adherence.
Results: A total of 411 (137 cases and 274 control) study participants were included in the study. The majority of
them were male in sex. Having 2 years and above duration on ART [AOR = 7, 95% CI (2.2, 22.6)], history of adverse
effect [AOR = 6.9, 95% CI (1.4, 32.9)], substance use [AOR = 5.3, 95% CI (1.4, 20.0)], living with parents [AOR = 3.4, 95%
CI (1.2, 10.3)], having depression symptom [AOR = 3.3, 95% CI (1.4, 7.5)], <350 cells/mm
3
cluster of differentiation 4
count [AOR = 3.2, 95% CI (1.8, 5.8)] and low dietary diversity [AOR = 2, 95% CI (1.1, 3.7)] were found significant determinants
of non-adherence
to
antiretroviral
drug.
Conclusion: Program, social and individual related factors showed a statistically significant associated with nonadherence
to
antiretroviral
therapy.
Managing
lifestyle
by
developing
self-efficacy
of individuals and treating
related
threat
to
improve
adherence
status of antiretroviral
therapy
is recommended
in this study.
Keywords: Antiretroviral therapy, Case–control study, Non-adherence, Northern Ethiopia
