Abstract:
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through
mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and
increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease,
and several findings indicate that multiple genetic and environmental factors are important
contributing factor involved in the pathogenesis of this disease. Recently great emphasis has
been given to genetical factors to combat the disease. The discovery of T2DM-associated
genes through genome wide association studies (GWAS) has provided insight into the genetic
architecture of T2DM, and several genes have been reported to be related to T2DM
susceptibility. One of these genes is PPARG -γ2 (Peroxisome proliferator-activated receptors
–gamma), which has been confirmed to be a potential type 2 diabetic risk for different ethnic
populations. It has been reported in the literature that, at the molecular level, PPAR-γ2Pro12
Ala gene polymorphism; the Pro allele has been associated with increased risk of diabetic 2 in
different population. On the other hand, the Ala allele of the PPAR-γ2 gene has been reported
to be strongly associated with reduced risk of the disease. The aim of the present study was to
assess the impact of PPAR-γ2 gene polymorphism on risk of diabetic type 2 patients visiting
Gondar University Teaching Hospital. One hundred diabetic-2 patients and an equal number
of age and sex matched control groups were recruited for this case control study from the
teaching hospital of the university.
