Abstract:
Despite different efforts made to intervene with
the deadly nature of HIV/AIDS, all attempts remained
unsuccessful due to complexity of the viral host interactions. The solution to HIV-1 pandemic is still to come, thus
to assist the efforts being made to intervene with the deadly
nature of the virus, different factors responsible for the
disease burdens have to be looked into a systematic manner. As a result, the present study aimed to find out the
association of IL-4 VNTR polymorphism with HIV-1
susceptibility and rate of disease progression. Three hundred cases and an equal number of sex and age matched
controls were included for this study. The polymerase
chain reaction assay was utilized to genotypeIL-4VNTR.
The results of this study showed statistically significant
variation among cases and controls in the distribution of
the Rp2/Rp2genotype (OR=0.36, 95% CI=0.18–0.69;
Pvalue=0.0014) indicating, thereby, a possibility of
reduced risk of HIV-1 susceptibility. Thus, Rp2/Rp2
genotype of theIL-4might have a role to play in reducing
risk of HIV-1 susceptibility among a north Indian
population.
