Abstract:
HIV/AIDS remains to be one of the killing
diseases of mankind. Host genetic response is one of the
factor which determine susceptibility to HIV and disease
progression to AIDS. The aim of the present study was to
evaluate the impact ofERCC2 Lyc
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Gln(excision repair
cross complementing rodent repair deficiency, complementation group 2) polymorphism on HIV-1 susceptibility
and disease progression to AIDS, as this gene has been
reported to intervene in degrading retroviral cDNA before
it integrates with the host DNA. This case control study
included 300 HIV seropositive cases and an equal number
of HIV seronegative controls. DNA was isolated from the
blood samples of study subjects and genotyping ofERCC2
was conducted by polymerase chain reaction (PCR) and
restriction fragment length polymorphism (RFLP) method.
The Gln/Glngenotype showed a significant variation
between cases and controls (P=0.047, OR 1.71, 95% CI
1.00–2.93), indicating a possible role of susceptibility in
reference to controls and disease progression when compared within cases
