Abstract:
ABSTRACT
Back ground: - Human immune deficiency virus infection (HIV) causes haematological
abnormalities including impaired haematopoiesis, immune-mediated cytopenias and
altered hemostasis mechanisms. Hemostasis system abnormality in HIV infected
individuals caused by endothelial dysfunction, presence of anti phospholipids antibody,
liver disease and bone marrow dysfunction.
Objective: To assess basic hemostatic profiles of HIV infected adults in correlation to
CD4 count and highly active antiretroviral therapy (HAART), at University of Gondar
hospital antiretroviral therapy clinic.
Methods:- A comparative - cross sectional study was conducted from February to May
2017, among 300 study participant, consists of 100 HAART-naive, 100 on-HAART
HIV-infected adults and 100 HIV-seronegative adults at University of Gondar hospital.
Venous blood was collected to perform coagulation tests (Prothrombin time (PT),
activated partial thromboplastin time (aPTT) and international normalization ratio (INR)),
cluster of differentiation 4 (CD4) count, platelet count and serological tests. The data
were entered, cleaned and edited using EPI info version 7 and analyzed using SPSS
version 20. Data were analyzed by using Kruskal Wallis H, Mann-Whitney U test and
Spearman correlation tests. Test result were expressed by median [interquartile] and
presented by using texts and tables. P-Value < 0.05 was considered as statistically
significant.
Results: - PT, aPTT and INR were significantly higher and platelet count significantly
lower in HIV infected adults (both on-HAART and HAART-naive) than HIVseronegative
adults (P <0.001). PT and INR were significantly higher and platelet counts
significantly lower in HAART-naive HIV infected adults than on-HAART HIV infected
adults (P<0.05). In spearman correlation test APTT of HAART-naive individuals was
inversely correlates with CD4 count. However, HAART duration did not show significant
difference in all parameters (P >0.05).
Conclusion and recommendation: - HIV infected adults are more likely to develop
coagulation abnormality than HIV-seronegative subjects. Coagulation test and platelet
count should be used to monitor coagulation disorder in HIV infected individuals.
