Abstract:
ABSTRACT
Background: Untreated significant bacteriuria during pregnancy may cause serious complications including pyelonephritis, cystitis and the result of adverse pregnant outcomes. However, screening of significant bacteriuria among asymptomatic pregnant women by gold standard culture not consider as essential part.
Objective: The aim of this study was to determine the prevalence of significant bacteriuria, antimicrobial susceptibility pattern of the isolates, associated risk factors among pregnant women attending Dessie Referral Hospital, Northeast Ethiopia.
Methods: A hospital-based cross-sectional study was conducted from February to May, 2017 among 358 asymptomatic pregnant women. Freshly voided midstream urine samples collected for each study participants, and processed at Dessie regional research microbiology laboratory with convectional culture and bio-chemical tests. A urine sample was considered significant bacteriuria (>103 cfu/ml for GBS and >105cfu/ml for other urobathogens). Isolates were tested against commonly used antimicrobials by using Kirby Bauer disc diffusion method according to CLSI guidelines. Data summarized and statistical tests done alyzed by using SPSS version 20. Result: A total of 358 pregnant women were enrolled during the study with mean age of 26.5years (SD 4.6, and ranges 19-43). The overall prevalence of significant bacteriuria was 56 (15.6%). The organism most commonly isolated were E.coli and S.aureus 18 (31%) each. E.coli and S.aureus were resistance to ampicillin (66.7%) and penicillin (94.44%) respectivly. The prevalence of multiple drug resistance isolates was 72.4 %. History of catheterization [AOR=2.28, 95% CI= (1.03-5.06)] and anaemia [AOR=4.98, 95% CI=(2.395-10.34) were statistical significant with prevalence of significant bacteriuria.
Conclusion and Recommendation: In this study, the prevalence of significant bacteriuria was comparable with the previous high reports. The status of significant bacteriuria and their antibiotic susceptibility test should be taken into consideration during the management of pregnant women, which visiting antenatal care.
Keywords: Asymptomatic bacteriuria, Drug susceptibility, pregnant women, Ethiopia
